不可以互换，wash是洗的意思，clean是清洁、扫除的意思，例如：

1、Her hair could have done with a wash.她的头发该洗一洗了。

2、Go and wash your hands they're absolutely black!洗洗手去，你的手脏极了！

3、He put half a load of washing in the machine.他把限量一半的衣物放进了洗衣机。