区别就是两者都是动词interfere +介词短语，但意思是不一样的，具体不同如下
interfere with 中文意思是干扰，干涉妨碍触动或弄坏乱动与……抵触
I try not to let work interfere with my personal life.我尽量不让工作干扰我的私生活。
interfere in的中文意思是vt. 干涉，干预
She had no right to interfere in what was plainly a family matter.这事明摆着是别人的家务事，她无权干涉。
interfere with / in的区别
表示“对立妨碍打扰”用interfere with
比如interfere with children's performance at school. 影响孩子在校表现
表示“干涉‘干预介入”用interfere in 比如说interfere in politics.干预政治.
