区别就是两者意思都可以表示逃跑，具体的不同如下

flee中文意思是v. 逃离，逃避，逃跑

The continuing tension has prompted more than half the inhabitants of the refugee camp to flee to safer areas.

escape中文意思是v. 逃跑，逃脱逃避，摆脱避开，避免（疾病或受伤等）泄露，逸出不自觉地说出被遗忘，被忽略去度假退出