区别在于:

prefer通常与to或者over搭配,表示更喜欢,偏好,宁愿的意思,很少会和with搭配,但并不是不可以和with连用,如:

Prefer with experience.

有经验者优先。

prefer to:

Children universally prefer to live in peace and security, even if that means living with only one parent.

孩子们普遍愿意过平静安宁的生活,即使那意味着只能和单亲生活在一起。